International Journal of Medical Science and Dental Research

Current Issue Volume 5 Issue 4 (July 2022)

    • Chronic Tibial Osteomyelitis; Use of Biactive Glass as an Alternative of Treatment. Report of a Case
      Chronic osteomyelitis is a disease usually of infectious origin. The main cause is post-traumatic, it affects the bone tissue and surrounding tissue, the most frequent causative agent is Staphylococcus aureus. The most affected bone is the tibia. Case description: A 42-year-old male with a diagnosis of chronic tibia osteomyelitis, with sequelae of previous surgical interventions, multiple antibiotic treatments, and type IV B classification by Cierny-Mader. Methods: Two-stage surgical management was chosen. Firstly, extensive bone and soft tissue debridement, placement of cement beads medicated with amikacin in the medullary cavity and osteoclast system for irrigation with vancomycin. In the second stage, free fibular bone grafting, fixation and stabilization with screws, bioactive glass placement in areas of interface between stabilized fibula and posterior tibial cortex. Results: Before a multitratada chronic osteomyelitis it is necessary to individualize and evaluate treatment alternatives, in this case the surgical management in two time, the use of medication beads, bone graft and the use of bioactive glass, achieved a complete eradication of the infection and favorable clinical evolution with optimal functional recovery of affected limb.

      Keywords:: Chronic osteomyelitis, Tibia, Bioactive glass.

      • Influence of bone marrow-derived mesenchymal stem cells versus low-level laser irradiation therapy on the rat parotid glands after streptozotocin- induced diabetes
        Objective: The current study was designed to assess the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSCs) versus low-level laser therapy (LLLT) on the rat parotid glands after streptozotocin induced diabetes in rats. Materials and Methods: 48 Sprague-Dawley rats were divided into 4 groups, 12 rats each. Group I: the animals received 0.1 M sodium citrate buffer intraperitoneally, the vehicle of streptozotocin. Group II: diabetes mellitus was induced by single intraperitoneal injection of 60 mg/kg of streptozotocin (STZ) dissolved in 0.1 M sodium citrate buffer. Group III: one day after diabetes induction, single dose of 2×106 BMSCs suspended in 0.5 ml of phosphate buffer solution (PBS) was injected via intraglandular route. Group IV: one day after diabetes induction; the animals were exposed to single session of LLLT on the right parotid gland area. Animals were sacrificed at 7 or 14 days after BMSCs injection or laser irradiation parotid glands were harvested, then histological and immunohistochemical studies were performed. Result: The experimental stem cell treated group showed better histological features and more PCNA proliferation than the laser treated group. Conclusion: bone marrow derived stem cell and laser treatment are successful method in the treatment of diabetic induced salivary gland injury, with relative superiority of stem cell treatment.

        Keywords:: Parotid gland, stem cells, laser- therapy, diabetes

        • Purple Sweet Potato Biscuits Affects Total Antioxidant Levels in Pregnant Women with Anemia
          Background: One of the causes of the high maternal mortality rate is anemia that occurs during pregnancy. The purpose of this study was to determine the effect of giving eel and purple sweet potato biscuits to total antioxidant levels in anemic pregnant women in the Pampang Public Health Center, Makassar City. Research methods: This study used experimental research methods with a Randomized Control Trial pretest-posttest design with a control group. The research was conducted in the working area of Pampang Public Health Center, Makassar City. The number of samples was 20 pregnant women who were divided into 2 groups, namely the control group and the comparison group. The data analysis used included Wilcoxon, Mann Whitney, Paired T-test, and Independent T-test. Research result. The results: of the Mann Whitney test showed that there was no significant effect on the total antioxidant levels of pregnant women between groups in the post-intervention condition (p=0.496>0.05). However, the Wilcoxon test results showed a significant effect in both the intervention group (p=0.005) and the control group (0.018 <0.05). Conclusion: It was concluded that giving eel biscuits and purple sweet potato could increase total antioxidant levels and albumin levels in anemic pregnant women in the working area of Pampang Public Health Center Makassar City.

          Keywords:: Eel, Purple Sweet Potato, Total Antioxidant, Albumin