VASCULAR CELL ADHESION MOLECULE-1 (VCAM-1) AND BLOOD PRESSURE ON PREECLAMSIA PATIENTSAbstract:
Preeclampsia refers to a systemic syndrome characterized by extensive maternal endothelial dysfunction clinically accompanied by hypertension, edema, and proteinuria during pregnancy. It occurs in about 3% to 5% of pregnant women, usually in the last trimester and is more common in primiparas (women who are pregnant for the first time. Some of these women progress to convulsions (eclampsia). Other complications stem from systemic endothelial dysfunction include acute renal failure and pulmonary edema.About 10% of women with severe preeclampsia have hemolysis, elevated liver enzymes, and low platelets, which is called hemolysis, elevated liver enzyme levels, and low platelet levels (HELLP syndrome). Pregnancy can trigger hypertension in women who were previously normotensive or can exacerbate the disease in women who previously had hypertension. The cause of both cases is unknown. Generalized edema, proteinuria, or both often accompany hypertension precipitated or exacerbated by pregnancy. This hypertension can be accompanied by seizures, especially if ignored . Hypertensive disorders that complicate pregnancy are common and are one of the elements that cause a large number of maternal deaths in the United States in addition to bleeding and infection, which continue to be. Most of the poor pregnancy outcomes associated with hypertension can be prevented with good prenatal monitoring and treatment if needed. Pregnancy hypertension is clinically pregnancy-induced hypertension. it was found that the correlation between maternal age and VCAM-1 levels did not have a correlation. These results were obtained by controlling for independent variables (systolic blood pressure and diastolic blood pressure) and intermediate variables (number of pregnancies). When statistical tests were carried out without controlling for systolic blood pressure, while other variables were controlled, there was a significant correlation between maternal age and VCAM-1 levels. Then the statistical test was carried out again by controlling only the systolic blood pressure variable and the other variables were not, then the obtained correlation was also not significant from maternal age and VCAM-1 levels.
Keywords: vascular cell adhesion, VCAM-1, blood pressure, preeclamsia patient.