Leptine and its Participation in the Development of ObesityAbstract:
Background: Obesity is a chronic, multifactorial disease that increases significantly in the world population, affecting both adults and children and adolescents. In addition, it can lead to developing other diseases. Leptin is a hormone that is produced in various tissues of the body, adipose tissue being the protagonist in this pathology; giving it great relevance in terms of its participation as a producer of substances that make it an active tissue.
Methodology: A narrative review was carried out, in which different databases were used, in English and Spanish languages, obtaining a total of 21 articles, 15 of which met the inclusion criteria.
Results: Obesity is generated due to an energy imbalance, between caloric intake and expenditure. Likewise, leptin varies, according to its intravascular concentration, it modulates food consumption, responding to fasting states and the presence of glucose, so that when a deficit of this occurs, obesity can arise either in isolation or in concomitance with other factors that also induce its development.
Conclusions: Leptin is a hormone that is produced in adipose tissue, which has various functions in the body. It is currently known to play an important role in the development of obesity. However, its mechanism of action must be further studied and elucidated so that as a drug many more results can be generated in favor of the treatment of this pathology.
Keywords:: Leptin, obesity, metabolism, adipose