International Journal of Medical Science and Dental Research

Volume 01, Issue 01 August 2018

    • Comparison of Two Point Discrimination of Palmar Surface of Distal Phalanx of Thumb between Dominant and Non Dominant in Labourers
      BACKGROUND:Two point discrimination test assess the ability to perceive two points applied to the skin simultaneously applied with equal pressures. The finger tips and palm of the hand are considered to be the most sensitive parts which perceive the two-point in a small distance when compared to other parts of the body.
      OBJECTIVE: To compare the tactile acuity of the thumb finger between dominant and non dominant hand n labourers.
      STUDY DESIGN :Observational study.
      PROCEDURE: Subjects were made to sit in a comfortable position and were asked them to close their eyes. With the aesthesiometer stimulus was given and were asked the subjects to perceive the points. Values were noted accordingly.
      RESULTS: . Mean and standard deviation of dominant hand is 2.627 and 0.5205. And of non dominant hand is 2.013 and 0.4954.
      CONCLUSION:This study concluded that there was a difference in tactile acuity of thumb in dominant and non dominant hand. It differesaccording to their profession and usage of dominant hand.

    • Formulation and development of floating microspheres containing levodopa and carbidopa
      ABSTRACT: The main objective of work to develop long acting sustained release floating microballons of levodopa and carbidopa by emulsion-solvent evaporation technique for the treatment of Parkinson,s disorder.All current levodopa products are formulated in combination with aromatic amino acid decorboxylase inhibitors such as benserazide to prevent the peripheral metabolism of levodopa.In the present research work was to produce floating microspheres of carbidopa and levodopa to enhance their efficacy by increasing their gastric retention time which is major technique to improve efficacy of narrow absorption window drugs, and its improved bioavailability.The effect of various formulation were evaluated and process variable on the particle size ,in vitro floating behavior, percentage yield and in vitro drug release were studies.Further,the microspheres could also be compressed in to tablets, filled in to capsule or formulated in to oral suspension for reconstitution.
      KEY WORDS: HPMC K15M, EC, Emulsion-solvent evaporation technique, Parkinson,s disorder.

    • Effects of Administering Soft Drinks on Some Biochemical Parameters and Histopathology of Liver in Wistar Rats
      ABSTRACT: The ruling of the Lagos High Court at Igbosere, Nigeria onthe 13th March, 2017 gave birth to this research work. The court ordered NAFDAC to enforce the Nigerian Bottling company(NBC) to write warnings on the potential dangers of taking soft drinks, especially with Vitamin C on their drinks. Twenty-five albino rats (weighing 194±9.5g) were randomly assigned to five groups (n=5). The soft drinks were labeled A, B, D, "A + Vitamin C" (400mg/20ml) and distilled water (control) were administered orally to groups 1, 2, 3, 4 and 5 respectively for 14 days. The administration was done in accordance with Pedro Montilla‟s method (400ml/70kg body weight).The rats were sacrificed and subjected to biochemical and histological analysis. The levels of AST, ALT, TB and DB for soft drinks B, A, D and "A+ Vitamin C" were significantly higher(P<0.05) than the control.This is a strong marker for potential liver dysfunction.Similarly,A and "A+ vitamin C" significantly increased(P<0.05)bad cholesterol while weight andhistological results of rats are normal. Moreover, the amount of soluble sugars found in D is more than double the level approved by the Standard Organization of Nigeria (SON).All the soft drinks are biological culprits as none is totally free of potential toxicity. This research supports the ruling of the High Court to include warnings of the potential dangers but consistently maintained that Vitamin C when added to soft drink A reduced its potential toxicity.
      KEY WORDS: lipid profile, liver, histology, LDL, A + vitamin C

    • Modification of Pectin-Glycine with Indomethacin to treatment the wound and inflammations
      ABSTRACT: This work included preparation new drug polymer as bio adhesive , which have high viscosity and treatment the wounds andexternal inflammation, because it remains inherent to the position of injury fast time, A new bio adhesivepolymer was prepared bymodification of Pectin structure with Glycine as a spacer substituted with drug such as Indomethacinproduced amide polymer. This design carries controlled delivery of therapeutic agents which could release the entrapped drug over an extended period of time due to its biodegradable, nontoxic and slow digesting nature. The prepared drug polymer wsa characterized by FTIR, 1H-NMR spectroscopes, thermo gravimetric analysis TGA and DSC were studied. intrinsic viscosities and Physical properties of all prepared polymer wsa measured, Biological activity was studied for drug polymer,this new adhesive drug biological polymers were applied on different infected mice and wounds, It gave good results and compliance mice infected with a full recovery by a short period of time.
      KEY WORDS: Pectin , Indomethacin,Glycine polymer,

    • Trismus Masquerading Embryonal Rhabdomyosarcoma- an extremely rare case report and literature review
      ABSTRACT: Rhabdomyosarcoma was first described by Weber1 in 1854. It is the most common soft tissue sarcoma and malignant orbital neoplasm in infants and children1, 2. It is a rare malignant tumour with extremely aggressive and infiltrative nature3, histologically;embryonal or botryoid type is the most common variant occurring in the head and neck region4. The alveolar type of rhabdomyosarcoma is mostly seen in extremities and trunk in children and young adults2. Here we present an extremely rare case of an embryonalrhabdomyosarcoma located in the maxillary sinus which extends into the orbital cavity with absolutely no ocular symptoms.
      KEY WORDS: Rhabdomyosarcoma; embryonalrhabdomyosarcoma; orbital rhabdomyosarcoma

    • Spectroscopic characterization and Bioactivty studies of new Co(II), Ni(II), Cu(II), Au(III) and Pt(IV) complexes with didentate (NO) donar azo dye ligand
      ABSTRACT: The.newligand(5-((4-(1-(p-tolylimino)ethyl)phenyl)diazenyl)pyrimidine -2,4,6(1H, 3H, 5H) -trione (R2) have been synthesized and characterized by micro elemental analysis ,(1H-13C) NMR, FT-IR, and UV-Vis spectroscopic techniques. (R2 ) acts as a ligand coordinating with some metal ions Co(II), Ni(II), Cu(II), Au(III) and Pt(IV) generated fife mononuclear metal complexes, represented as [CoR2Cl2(H2O)2] (a) ,[NiR2Cl2] (b),[CuR2Cl2] (c),[Pt(R2)2 Cl2 ] Cl2 (d) , [Au(R2)2]Cl3(e) .The Structures of the new compounds were characterized by elemental , FT-IR and UV-Vis Spectra. The magnetic properties and electrical conductivities of metal complexes were also determined. The anticancer activity for (R2) and its metal complexes complexes have been extensively studied on AMGM cancer cell line.
      KEY WORDS: Azo Schiff complexes,AzoBarbituric complexes , barbituric complexes , Pyrimiden complexes , anticancer activity , MTT assay.