Vascular pathology of diabetic foot: A review articleAbstract:
Background: The frequency of diabetes has increased significantly during the past decade.Although diabetic complications diabetic foot is the most serious diabetic complication, its pathophysiology has not been well recognizedby the medical community. Medical publications have introduced etiologies for diabetic foot. With this in mind,this review article was performed to evaluate vascular pathology of diabetic foot in diabetic patients.
Methods: We searched for articles published between January 1986 and June 2016 (30 years). Out of389 articles, we excluded 381 articles based on exclusion criteria and retained 7 for data extraction. From these 7 articles, 4 articles were observational, and 3 articles were used as a randomized controlled trial (RCT).
Results:5 out of these 7 selected articles showed that atherosclerosis is the etiology of vasculopathy, including anincrease in ox-LDL and ischemia-modified albumin, a decrease in paraoxonase 1, anincrease in the number of mature dendritic cells, and decrease in the number tolerogenic dendritic cells. Only one case report found that thrombosis may be involved in the development of diabetic foot, and states that this is the first time that deep vein thrombosis has been reported as the etiology of diabetic foot. In only one case report itwas found that leukocytoclastic vasculitis may cause diabetic foot.The other etiologies that have been mentioned as other factors causing diabetic foot (etc. vasospasm), no study has been done to verify these claims.
Conclusion: According to the 7 mentioned studies, we can prescribe medicines tailored forthese mechanisms in diabetic patients in order to prevent diabetic foot.
Ethical number registration: IR.SSU.MEDICINE.REC.1394.310.
Keywords: Diabetic foot, Pathology,Vasculitis, Atherosclerosis, Vascular diseases