International Journal of Medical Science and Dental Research

Volume 4 Issue 3 (May-June 2021)

    • A Case Report of Infiltrating Ductal Carcinoma of Breast
      A 60-year-old woman was admitted to our hospital for nipple retraction. Diagnosis: Fine needle biopsy of the breast lesion and surgical resection found infiltrating ductal carcinoma (Intermediate grade) of right breast; with involvement of nipple and metastasis to axillary lymph node. Interventions: The patient underwent modified radical mastectomy and the biopsy of a surgical specimen was identified as infiltrating ductal carcinoma cancer. Then the patient was treated with chemotherapy and hormone therapy. Outcomes: The patient remained symptom-free during 4 months of follow-up examinations.

      • Evaluation of the Efficacy of PRF as a Bone Substitute Material Alternative to Xenograft in Critical-Sized Bone Defects in Periradicular Surgery: an Animal Study. ABSTRACT:
        The study evaluated platelet-rich fibrin (PRF) alone and in combination with Xenograft as an alternative to bone substitute in the treatment of critical-sized bone defects in dogs. Methods:Eight healthy adult male dogs were included according to the power study. Root canal treatment of the mandibular 2nd and 4th premolar teeth in both sides was done. Two critical-sized bone defects (7 mm × 7 mm × 7 mm each)were createdin each side of the mandible in relation to the distal root of the selected teeth (32 bone defects). According to the bone cavity filling materials used there were four groups: Xenograft (X), Xenograft and PRF (X and PRF), PRF and Blood Clot groups (BC). The animals were sacrificed at 4 days, 2 weeks, 5 weeks and 9 weeks after the treatment and the mandibles were harvested. Dual-energy X-ray absorptiometry evaluation (DEXA)was done to evaluate the bone density at the defects. A histological evaluation was done to evaluate new bone formation. Results: At four - day scarification period, the highest bone density was observed in the X group (0.602 ± 0.012) followed by X and PRF (0.521 ± 0.012), PRF (0.163 ± 0.024) and BC (0.102 ± 0.024) groups (p < 0.001). At 9-weeks, the highest bone density was observed in the X and PRF group (1.325 ± 0.029), followed by X (1.04 ± 0.023) and PRF (1.05 ± 0.035) groups (p < 0.001) with no significant difference between X and PRF groups. Histologically X and PRF group showed the highest new woven bone formation at 9 weeks. Conclusion: PRF is a valuable material that can be used as a grafting material in periradicular surgery to improve bone regeneration.

        Keywords: Bone regeneration, bone substitutes, bone density, platelet-rich fibrin, xenograft.

        • Analysis of Ft4 and Tsh Levels in Controlled and Uncontrolled Type 2 Diabetes Patients ABSTRACT:
          Diabetes melitus (DM) is a group of metabolic disease with the characteristic of hyperglycemia which occurs due to disturbance in insulin secretion, insulin work, or both. Diabetes melitus and thyroid disorder are endocrine disorders that are closely associated each other. This study aimed to determine the correlation between thyroid function in controlled and uncontrolled type 2 DM patients. This is a retrospective study using secondary data from medical record. Data were collected from patients diagnosed with type 2 DM by the clinicians and were categorized into controlled and uncontrolled type 2 DM with FT4 and TSH assessment data. Data were analyzed with Independent T-Test and Mann-Whitney test using SPSS. This study investigated 53 participants, divided into controlled DM (18.9%) and uncontrolled DM (81.1%). The population was dominated by females (75.5%) with the average age of 57.45 years old. The prevalence of thyroid function in this study were normal (84.95%), subclinical hyperthyroid (9.4%), and hyperthyroid (5.7%). There was no significant difference found in FT4 and TSH levels between controlled and uncontrolled type 2 DM patients with FT4 level (1.46 ng/dl ± 0.59 vs 1.36 ng/dl ± 0.66, p = 0.490) and TSH (1.66 µIU/ml ± 1.13 vs 1.07 µIU/ml ± 0.05, p = 0.515). Conclusion: There was no significant difference of FT4 and TSH levels between controlled and uncontrolled type 2 DM

          Keywords: FT4, TSH, Type 2 Diabetes Melitus

          • Effect of Adding nano titanium Dioxide and Chitosan On Antibacterial, Water Sorption and Solubility of Glass Ionomer Cement ABSTRACT:
            To evaluate the water sorption, solubility and antibacterial activity of glass ionomer cement incorporating nano-titanium dioxide as well as chitosan. MATERIALAND METHODS:
            The samples were prepared in six groups, including non-modifed GIGs (NMGIC, n = 12), chitosan incorporated GICs (CHGIC, n = 12),3% nanotitanium incorporated GICs (nanoTio2GIC, n = 12), 5% nanotitanium incorporated GICs (nanoTio2GIC, n = 12), chitosan/3% nanotitanium incorporated GICs (CH/nanoTio2/GICs, n = 12),chitosan/5% nanotitanium incorporated GICs (CH/nanoTio2/GICs, n = 12) .The antibacterial activity was evaluated using a direct contact test against Streptococcus mutans. The water sorption and solubility of modified glass ionomer cement were evaluated. Data were analyzed using the ANOVA and Tukey tests. Statistical significance was set at the 0.05 probability level.
            With the dual-modification, a significant improvement in the antibacterial properties was found.However, no difference was found in water sorption. CONCLUSION:
            Under the limitations of the present investigation, the following conclusion can be drawn:5% wt TiO2 NP modified GIC powder with the chitosan modified GIC liquid (Group 5) exhibited the highest antibacterial activity against S. mutans.