International Journal of Medical Science and Dental Research

Volume 5 Issue 1 (January-February 2022)

    • Effect of Adding Chicken eggs hell powder on Solubility and Bioactivity of Some Types of Calcium Silicate Based Materials
      OBJECTIVE: To evaluate thesolubility and bioactivity of some types of calcium silicate-based materials incorporating chicken eggshell powder (CESP).
      MATERIALAND METHODS: The samples were prepared in eight groups, including non-modifiedglass ionomer (NMGIC, n = 10), 1% eggshell incorporated GICs (ESGIC, n = 10),3% eggshell incorporated GICs (ESGIC, n = 10), 5% eggshell incorporated GICs (eggshell GIC, n = 10), non-modified biodentine (NMBD, n = 10),1% eggshell incorporated BD (ESBD, n = 10),3% eggshell incorporated BD,(n= 10) 5% eggshell incorporated BD(n = 10). The solubility of modifiedcalcium silicate-based materials wasevaluated. Thesamples of bioactivity were immersed in simulating body fluid for 1month.Samples were then examined by scanning electron microscopeand energy disperse x ray spectroscopyto examine interfacial layer and Ca/P ratio.
      RESULTS: A significantincrease in solubility of modified calcium silicate-based materials was found. Also,the interfacial layer can be seen in GIC and BD groups that modified with ESP. There was a statistically significant difference in the Ca/P ratio among all investigated groups. CONCLUSION: Addition of ESP to GIC and BD can increase solubility of materials and improve the mineral deposition at dentine/ material interface.

      Keywords:: bioactivity, biodentine, eggshell powder, solubility, glass ionomer.

    • Bioactivity, Water Sorption and Solubility of Sol-Gel Formulated Glass-Ionomer Cement Modified With Nano-Fluorapatite
      OBJECTIVE:To assess the bioactivity, water sorption and solubility of sol-gel formulated glass-ionomer cement (FGIC) (60%SiO2, 35%CaO, 5%P2O5) with and without incorporation of Nano-fluorapatite (Nano-FAp) regarding to the commercial glass ionomer cement (CGIC).
      MATERIAL AND METHODS: The tested glass-ionomer cement was formulated by sol-gel method and nano-fluorapatite was incorporated into this formulated glass-ionomer with different percentages (1wt%, 2wt%, 3wt%, and 4wt %). A total number of 216 samples were used in this study. The samples were categorized in six groups; group1 CGIC (negative control), group 2; FGIC (positive control), group 3; FGIC/1wt% Nano-FAp, group 4; FGIC/2wt% Nano-FAp, group 5; FGIC/3wt% Nano-FAp; and Group 6; FGIC/4wt% Nano-FAp. Each group was subdivided into two subgroups of (18) samples each according to type of the test.The samples were characterized and tested for bioactivity after immersion in simulating body fluid (SBF) for 28 days, and for water sorption and solubility after 7 days of immersion in distilled water. One-way ANOVA tests was used to analyze data statistical significant is stablished at probability level of 0.05.
      RESULTS: FGIC recorded higher Ca/P ratio when compared to CGIC and this ratio increases with the increase of the percentage of the added nano-FAp. Also, FGIC recorded higher water sorption and solubility when compared to CGIC and its water sorption and solubility decreased when the amount of added nano-FAp increased.
      CONCLUSION: The sol-gel formulated GIC has higher bioactivity, higher water sorption and solubility than the commercial GIC. However, the incorporation of nano-FAp improves the bioactivity of this sol-gel formulated GIC and decreases its water sorption and solubility along with the increases in concentrations.

    • Evaluation of Vertical Marginal Gap of Long Span Implant Supported Fixed Dental Prostheses Fabricated with different CAD/CAM Materials
      Long span implant prosthetic materials capable of reducing biological or mechanical violation on the implants and supporting structures are highly required. With the introduction of high-performance polymers, this situation should be evaluated.
      To evaluate the vertical marginal gap of CAD/CAM long span implant supported fixed dental prostheses fabricated from polyetherketoneketone (PEKK) compared to Polyetheretherketone (PEEK) and zirconia.
      Material and methods:
      Two implants with straight abutments were inserted in a metal model representing lower first premolar and second molar. Twenty-one frameworks of fourunit FDPs were milled with three materials; PEKK, PEEK and Zirconia, and divided according to type of material into three groups (n = 7). The Vertical marginal gap of cemented frameworks was measured using stereo microscope (3˗MA 100 Nikon stereo microscope Japan) at 70x magnification. For each specimen; four shots were captured, then the images were transferred to an image analysis software (Omnimet Buehler USA) for vertical marginal gap evaluation.
      The mean marginal gab values were [64.28 ± 17.06 μm], [66.54 ± 14.16 μm] and [58.82 ± 11.64 μm] for the PEEK, PEKK and Zirconia groups respectively. There were no statistically significant differences between the PEEK and PEKK groups while both of the two groups increase significantly than the zirconia group.
      The vertical marginal gap values of the long span implant supported FDPs were affected by the material type. The obtained results were all within the clinically accepted range.

      Keywords:: Framework, Marginal gap, PEEK, PEKK, Zirconia

    • Bioactivity and Phytochemical Compound Test on Black Betel Leaves (Piper betle var. nigra) A Literature Review
      Indonesia has abundant biodiversity throughout its land and seas. The use of plants as treatment has been carried out for a long time by people in Indonesia. Biodiversity Indonesia has abundant potential herbal plants. One of the potential herbal plants is the black betel leaf (Piper betel). The people of Indonesia have long used black betel. Black betel leaf contains phytochemical compounds, namely alkaloids, saponins, tannins, and flavonoids. Empirically, this plant has been used by the community for several uses and also has many bioactivities, namely as an antiseptic, analgesic, antioxidant, antibacterial, antidiarrheal, anti-inflammatory, and other activities that are good for the body where it is hoped that this plant can be developed into output in the form of products that are good for the body. The community can use it. The results of a journal search where we found many secondary compounds found in black betel leaf, which are in the flavonoid, terpenoid, alkaloid, and other groups, besides that we found several activities that were scientifically recorded, including antibacterial, antioxidant, antihyperglycemic, antifungal activity. and others. Black betel leaf has many activities, including antioxidant, antibacterial, anti-inflammatory, antihyperglycemic, and others supported by supporting secondary compounds.

      Keywords:: Black Betel Leaf, Phytochemistry, bioactivity, Piper betel, potency

    • The Efficacy of Secondary Metabolit Compounds in Keledang Plant (Artocarpus lanceifolius) as Anticytoxic: Literature Review
      Cancer is a disease characterized by the presence of eccentric cells that can grow uncontrollably and have the competency to assail, move cells and body tissues. Indonesia as the second most sizably voluminous megabiodervisty in the world with abundant flora diversity with sundry benefits. The keledang plant is empirically kenned to be efficacious as an anticytotoxic. The purport of the literature review is to review the content of secondary metabolites and the bioactivity of the keledang plant in inhibiting cancer cell magnification. Methods utilized in article search reviewing national and international journals that have been scopus indexed, accredited by SINTA utilizing the Pubmed, Google Philomath and Researchgate platforms.Systematic Literature Review (SLR) design is a systematic literature review by identifying, assessing and interpreting all findings on one research topic.The results of the study obtained that the keledang plant yielded sundry isoprenylated flavonoid compounds containing isoprenyl side chain at C-3, 2,4-dioxygenated or 2,4,5-trioxygenated pattern in ring B of 2,3 flavone framework, exhibiting consequential cytotoxic effect on murine leukemia P-388 cells. Artobiloxanthone binds to the active site of the enzyme transglutaminase 2 (TG2), this enzyme as an anticancer target.

      Keywords:: Anticytotoxic, Artocarpus lanceifolius, Cancer, Secondary metabolites, Keledang plant.

    • A Comparative Evaluation of the Efficacy of Three Different Treatment Modalities in Dentin Hypersensitivity Management (An In Vivo Study)
      Objective : This study was conducted to evaluate the clinical effect of three different treatment modalities in management of dentin hypersensitivity.
      patients and methods: Twenty seven hypersensitive teeth from nine patients were enrolled for this study. Patients were randomly divided into three groups according to desensitizing agents (Citrine varnish, Charm varnish and Gluma adhesive) . Patients assessment of dentin hypersensitivity was done before application of the agent (baseline) then 1 week, 4 weeks and 3 months respectively. Patients were asked to rate their perception to air stimuli by using and Visual Analogue Scale (VAS).
      Results: The results of this clinical study revealed that there was high significant difference (p ≤ 0.05) between pain scores before and after treatment for all tested groups. Totally there was statistically significant difference (p ≤ 0.05) between the three groups as proven by Chi square test where Citrine varnish group was the highest followed by charm sense varnish group and the lowest was Gluma group in management of dentin hypersensitivity.
      Conclusions: Citrine varnish , Charm varnish and Gluma were effective occluding dentinal tubules and alleviating the hypersensitivity symptoms, with citrine varnish being the most effective within 1 to 2 weeks and sustained up to 3 months.

      Keywords:: Dentin hypersensitivity, Dentin desensitizing agents, Sodium fluoride , Gluma.

    • Antibacterial Activity of Zinc Oxide and Copper Oxide Nanocomposite
      Nanotechnology has recently emerged as a critical antimicrobial strategy. We developed a novel fluoride-containing zinc-copper nanocomposite (FZC). This study aimed to investigate the antibacterial effect of the nanocomposite and its effect on cell activity.A fluoride-containing zinc-copper nanocomposite (FZC) was synthesized according to the previous study and observed SEM.We analyzed the antibiotic susceptibility of S. mutans (ATCC 25175) to different concentrations of FZC. The bacterial were cultured in BHI medium with FZC and incubated for 24 h at 37°C. The antibacterial effect was calculated by the colony-forming units (CFUs). Cell viability assay was measured using hDPSCs cultured with Dulbecco's modified Eagle's medium and 10% aqueous solution. After that, Cell viability was measured by the Cell counting Kit-8. The control BHI medium allowed bacterial growth, whereas Ca (OH)2 and ZCF(350 mg/ml, 87.5 mg/ml, 21.9 mg/ml) allowed no bacterial growth. The cell activity of FCZ was 80% that of the control.The fluoride-containing zinc-copper nanocomposite developed in this study had higher antimicrobial activity than calcium hydroxide. Even if it's diluted 1000 times, it showed a little antibacterial effect. However, it affects cell activity with no lethal effects.

      Keywords:: Antibacterial activity, Biomaterial, Cell viability, Nanocomposite

    • Garengeot's Hernia as a Clinical Manifestation of Acute Appendicitis in the Inguinal Region
      An elderly woman admitted due to an inguinal tumor, highly suggestive of an inflammatory process, echography a collection compatible with an inguinal abscess; tomographic study shows a probable Garengeot's hernia versus Amyand's hernia. Patient had an inguinal approach, abscess drainage, exploratory laparotomy and reduction of the cecum and appendix, with subsequent appendectomy, a parietal peritoneal raffia was performed at the level of the crural canal; the inguinal wound is left open and the abdominal wall closed. Patient goes to hospitalization where she continues with antibiotic management and daily ealing of contaminated wound, the patient was discharge in 12 day

      Keywords::Garengeot's hernia, inguinal tumor

    • Analysis of Hemoglobin Levels on Menstrual Duration in Students for the 2017 Class of Faculty of Medicine University Muslim Indonesia
      Hemoglobin (Hb) which is the main component of red blood cells (RBC) is a conjugated protein that functions as the transport of oxygen (O2) from the lungs to the tissues and carbon dioxide (CO2). Anemia is a common condition diagnosed based on laboratory results in which the hemoglobin concentration is abnormally low or the red blood cell count is decreased. Anemia in adolescent girls is still quite high, according to the World Health Organization (WHO, 2013), the prevalence of anemia in the world ranges from 40-88%. Adolescent girls have a ten times greater risk of suffering from anemia compared to young men. This is because young women experience menstruation every month and are in a period of growth so they need more iron intake. The purpose of the study was to determine the relationship between the length of menstruation and changes in hemoglobin levels in FK UMI students class 2017. This study used a descriptive analytical observational research design with a cross-sectional approach. The population in this study were students of the Faculty of Medicine, Muslim University of Indonesia class 2017. The sample size in this study used a purposive sampling technique, namely all students of the UMI medical faculty class 2017. Data analysis was carried out by univariate and bivariate analysis. The results of the study showed that 91.2% of female students had normal menstrual periods and 8.8% had hypermenorrhea. Changes in female Hb levels before and during menstruation were found to be 61.8% decreased and 38.2% increased. Based on data analysis, it can be concluded that there is no relationship between the length of menstruation and changes in hemoglobin levels in respondents.

      Keywords:: Hemoglobin, Menstruation, Faculty of Medicine, University of Muslim Indonesia

    • Osteosynthesis of Fractured Mandibular Angle by Titanium 3-Dimensional Miniplate
      Osteosynthesis of fractured fragments at the mandibular angle region proves to be a controversial topic. Many studies have shown that no single approach to fixation is ideal. Champy's plate is vulnerable to torsional and bending forces along the long axis of the mandible leading to flaring of fragments, loss of friction lock and result in reduced primary stability. 3 Dimensional (3D) miniplate consisting of two miniplates joined by interconnecting struts that act as a single unit. The plate is strong enough yet malleable facilitating stabilization both at superior and inferior borders. This study was carried out to evaluate the efficacy of 3D titanium mini plate for fixation of mandibular angle fractures.
      Materials and Methods: This randomized prospective study consisted of 10 patients who met the inclusion and exclusion criteria. The patients were selected irrespective of the age, sex and socioeconomic status, presenting with mandibular angle fracture with or without associated secondary fractures. 3D titanium miniplate was used for fixation of fracture and patients were followed up for 4 months postoperatively.
      Results: The mean interval between initial trauma to definitive fixation (IT-DF) was 4.7 days and mean time interval for plate adaptation to definitive fixation (PA-DF) intraoperatively was 26 minutes. No patients sustained any infections or permanent complications postoperatively and functional return to normal was adequate.
      Conclusion: 3D titanium miniplate is an excellent choice for fast as well as reliably stable fixation of mandibular angle fractures.

      Keywords:: 3-Dimensional, Angle Fracture, Mandible, Osteosynthesis, Titanium miniplate

    • Dental Health Status of Student Dormitory Residents in Yogyakarta, Indonesia
      Background: Bad oral and dental hygiene in a person can cause dental caries. One indicator of dental health status is using the status of oral hygiene and dental caries status.
      Objective: This study aims to determine the dental health status of students living in dormitories in Yogyakarta.
      Methods: This research is descriptive with a cross sectional research design. The sample of this study were students living in a dormitory in Yogyakarta using purposive sampling technique with inclusion criteria of respondents being in good health and willing to be respondents. The research data was obtained from the format for checking the status of oral hygiene and dental caries status using oral diagnostic tools, namely mouth mirror and sonde. Data analysis is presented in the form of cross tabulation.
      Results: the dental and oral hygiene status of dormitory students with good criteria was 47.5%, and dental caries status was 80% high.
      Conclusion: The dental health status of students dormitory residents in Yogyakarta is categorized as moderate.

      Keywords:: Dental health status, student, dormitory resident

    • Effect of Invasive and Non-Invasive Techniques on laser fluresence score and retention of Two Pit and Fissure Sealants (in vivo study)
      Objective: This study was conducted to compare clinical effect of invasive and non-invasive techniques on diagnodent pen score and retention of two pit and fissure sealants. Patients and methods: Total of (84) first permanent molar teeth were sealed in 21 participants aged between 8-12 years enrolled in the study.Baseline Measurements with DIAGNOdent pen were performed on the occlusal surface of each molar tooth. Teeth were randomly assigned into two groups (n=42). A1; Healioseal f. A2; Tetric flow. The sealants were applied by B1, invasive and B2 non-invasive techniques. Participants recalled at 1 week, 1 month and 3 months. Results: Gr_A1 recorded higher fluorescence score mean value than Gr_A2. The difference was statistically non-significant (p> 0.05). Gr_B1 recorded higher fluorescence score mean value than Gr_B2. The difference was statistically non-significant (p> 0.05). The highest fluorescence score mean value recorded after one week storage followed by 1 month storage while the lowest fluorescence score mean value recorded after 3 months storage. The difference was statistically non-significant as proved by Chi square test (p> 0.05). Gr_A1 recorded higher success score % value than Gr_A2 group. The difference was statistically significant as revealed by Chi square test (p< 0.05).the highest success score % recorded after one week,, while the lowest success score % recorded after 3 months with statistically significant difference as proved by Chi square test (p< 0.05).Conclusions: resin based fissure sealant demonstrates effectiveness in caries prevention and retention.

      Keywords:: Diagnodent pen, Helioseal F, Invasive , Retention, Tetric Flow

      • The Impact of Using Nano zeolite around Immediate Dental Implant. (A Novel Clinical Study)
        Purpose: The present study was designed to evaluate the clinical, radiographic and biochemical efficacy of nano zeolite with immediate dental implant. Patients and Methods: In this study a single immediate implant at a maxillary anterior teeth were performed on 30 patients who were divided randomely into two equal groups Group I: Patients received immediate dental implant alone. Group II: Patients received immediate dental implant with locally applied Nano zeolite. Clinical and radiographic parameters were recorded for all implants at baseline, 6 and 12 months. Moreover, Implant stability was assessed immediately after implant insertion and six months post-operatively. Biochemical analysis for RANKL levels in periimplant crevicular fluid were assessed at baseline, 4 weeks and 3 months.
        Results: Regarding clinical parameters, modified plaque index (mPI), modified sulcular bleeding index (mBI) and peri implant probing depth (PPD), no statistically significant difference was found between both groups at the different intervals. While implant stability showed statistically significant difference to group II in relation to group I at 6 months. Regarding marginal bone loss (MBL) and bone density, statistically significant differences to group II in relation to group I were found at 6 and 12 months. Regarding biochemical analysis for RANKL levels, no statistically significant difference was found between both groups at different intervals.
        Conclusions: Nano zeolite showed promising clinical and radiographic results and can be used as a new effective bone graft material around immediate dental implant.