Correlation and Prediction Value of Glycemic Control (Hba1c) and Duration of Diabetes Mellitus on Cognitive Impairment
Abstract:Diabetes mellitus is a disease characterized by hyperglycemia and disorders of carbohydrate, fat and protein metabolism which are associated with absolute or relative deficiencies in insulin action or secretion. There are many insulin receptors in the brain. Some have a role in glucose transport, and some are thought to have a role in cognitive processes.
Objective: This study aims to determine the correlation and predictive value of glycemic status and duration of suffering from DM on impaired cognitive function.
Method: Observational analytical study with a cross sectional design involving 100 research subjects with type 2 DM who met the inclusion criteria. Subjects were categorized into groups with controlled (HbA1c ≤7%) and uncontrolled (HbA1c ≥7%) glycemic status. Cognitive function was assessed using the Indonesian version of the Montreal Cognitive Assessment (Moca-Ina). Results: There was a significant relationship between HbA1c levels and impaired cognitive function (p=0.000) and there was a significant relationship between the duration of suffering from DM and cognitive function. (p=0.001). HbA1c levels were significantly positively correlated with the Moca-Ina score (p=0.000) (R= -1.044), apart from that, the duration of suffering from DM was also significantly correlated with the Moca-Ina Score (p =0.001) (R=-7.752). In the ROC curve analysis, it was found that the area under the curve (AUC) of Hba1c was 96.3% with a cut off value of 7.5% and sensitivity of 89.71%
Keywords:: Glycemic Control, HbA1c, Diabetes Mellitus, Cognitive Impairment